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Dre Fabienne Picard

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Rue Gabrielle-Perret-Gentil 4
1205 Genève
Suisse

Bâtiment Stern, 2è étage

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Photo du médecin-chef Andreas Kleinschmidt
Professeur
Andreas Kleinschmidt
Médecin-chef de service

Médecin adjointe agrégée

La Dre Fabienne Picard est médecin adjointe dans l’Unité d’épileptologie du Service de neurologie des HUG, et professeure associée à la Faculté de médecine de l’Université de Genève depuis septembre 2019. Elle a suivi sa formation de médecine et de spécialiste en neurologie à l’Université Louis Pasteur de Strasbourg en France, où elle a également obtenu un Diplôme d’études approfondies (DEA) en biologie cellulaire et moléculaire (équivalent de master). 

Au niveau clinique, elle s’implique ces dernières années dans le projet Première crise mis en place en mai 2021 aux HUG et permettant une hospitalisation immédiate et un bilan complet précoce suite à une suspicion de première crise épileptique (avec EEG de veille et sommeil et IRM cérébrale). 

Entre autres fonctions, elle est responsable depuis 2017 de la cellule médicaments (Commission des médicaments) pour le Département des neurosciences cliniques des HUG, membre de l’Instance de discipline médecine clinique de la Bibliothèque de l’Université de Genève / site Centre médical universitaire, et membre du board de la Ligue suisse contre l’épilepsie depuis 2021.

Ses intérêts principaux de recherche ont été la génétique des épilepsies focales familiales, avec un intérêt particulier pour les récepteurs nicotiniques cérébraux, et plus récemment l’épilepsie focale dite extatique, pour laquelle elle a amené de nouvelles connaissances avec mise en évidence de l’implication majeure de l’insula antérieure. Elle a pu ainsi étayer le rôle de l’insula dans la conscience de soi. Certains de ses travaux ont été soutenus par le Fonds national suisse. 

Elle a publié plus d’une centaine d’articles dans des journaux à politique éditoriale.

Publications significatives

Epilepsie extatique

  1. Picard F, Craig AD. Ecstatic epileptic seizures: a potential window on the neural basis for human self-awareness. Epilepsy Behav 2009; 16: 539-546. doi.org/10.1016/j.yebeh.2009.09.013.
  2. Gschwind M, Picard F. Ecstatic epileptic seizures: a glimpse into the multiple roles of the insula. Front Behav Neurosci 2016; 10:21.doi: 10.3389/fnbeh.2016.00021
  3. Bartolomei F, Lagarde S, Scavarda D, Carron R, Bénar CG, Picard F. The role of the dorsal anterior insula in ecstatic sensation revealed by direct electrical brain stimulation. Brain Stim 2019; 12(5):1121-1126. doi:10.1016/j.brs.2019.06.005
  4. Conférence semaine du cerveau Genève 2023. La conscience dans tous ses états.
  5. Picard F. Ecstatic epileptic seizures. J Cogn Neurosci 2023; 35: 1372-1381. doi:10.1162/jocn_a_02031

Récepteurs nicotiniques cérébraux 

  1. Picard F, Bruel D, Servent D, Saba W, Fruchart-Gaillard C, Schöllhorn-Peyronneau M-A, Roumenov D, Brodtkorb E, Zuberi S, Gambardella A, Steinborn B, Hufnagel A, Valette H, Bottlaender M. Alteration of the in vivo nicotinic receptor density in ADNFLE patients: a PET study. Brain 2006;129(8):2047-2060. doi:10.1093/brain/awl156
  2. Picard F, Sadaghiani S, Leroy C, Courvoisier D, Maroy R, Bottlaender M. High density of nicotinic receptors in the cingulo-insular network. NeuroImage 2013;79:42 51. doi:10.1016/j.neuroimage.2013.04.074

Génétique des épilepsies

  1. Picard F, Baulac S, Kahane P, Hirsch E, Sebastianelli R, Thomas P, Vigevano F, Genton P, Guerrini R, Gericke CA, An I, Rudolf G, Herman A, Brice A, Marescaux C, LeGuern E. Dominant partial epilepsies: a clinical, electrophysiological and genetic study of 19 European families. Brain 2000; 123: 1247-1262. doi.org/10.1093/brain/123.6.1247
  2. Baulac S, Ishida S, Marsan E, Miquel C, Biraben A, Nguyen DK, Nordli D, Cossette P, Nguyen S, Lambrecq V, Vlaicu M, Daniau M, Bielle F, Andermann E, Andermann F, Leguern E, Chassoux F, Picard F. Familial focal epilepsy with focal cortical dysplasia due to DEPDC5 mutations. Ann Neurol 2015; 77: 675-683. doi: 10.1002/ana.24368
  3. Picard F, Makrythanasis P, Navarro V, Ishida S, de Bellescize J, Ville D, Vasselon Raina M, Lesca G, An-Gourfinkel I, Baulac M, Mundwiller E, Couarch P,  Antonarakis SE, Leguern E, Steinlein O, Baulac S. DEPDC5 mutations in families presenting as autosomal dominant nocturnal frontal lobe epilepsy. Neurology 2014; 82: 2101-2106. doi:10.1212/WNL.0000000000000488
Liste des publications
  1. A. Silva Alves, I. Rigoni, P. Mégevand, S. Lagarde, F. Picard, M. Seeck, S. Vulliemoz, N. Roehri. High-density EEG functional networks in genetic generalized epilepsy: preserved whole-brain topology hides local reorganization. Epilepsia 2024 (in press). Doi: 10.1111/epi.17903
  2. G. Sansone, P. Megevand, S. Vulliemoz, M. Corbetta, F. Picard, M. Seeck. Long-term outcome of alcohol withdrawal seizures. Eur J Neurol 2024; 31 (1): e16075. Doi: 10.1111/ene.16075
  3. E. Ménétré, P. de Stefano, P. Megevand, F. Sarasin, M. Vargaz Gomes, A. Kleinschmidt, S. Vulliemoz, F. Picard, M. Seeck. Antiseizure medication ≤48 hours portends better prognosis in new onset epilepsy. Eur J Neurol 2023. Doi: 10.1111/ene.16107
  4. P. De Stefano, E. Ménétré, P. Stancu, P. Megevand, M.I. Vargas,  A. Kleinschmidt, S. Vulliemoz, R. Wiest, S. Beniczky, F. Picard, M. Seeck. The added value of advanced workup after the first seizure: a 7-year-cohort study. Epilepsia 2023; 64 (12): 3246-3256. Doi: 10.1111/epi.17771
  5. E.B. Hammar, J. Baiao Botos, F. Baleydier, J. Barasche, G. Blanchard, J-L. Blouin, C. Borradori Tolsa, H. Cao Van, D. Carballo, F. Chalard, V. Fleury, J. Flüss, S. Fokstuen, S. Garcia-Tarodo, A. Giacobino, N. Goossens, M. Guipponi, R. Ha Vinh Leuchter, S. Hanquinet, A-M Hübers, P. Hüppi, P. Jandus, I. Kern, C. Korff, P. Lalive, S. Laurent, A. Lobrinus, E. Marchionni, C. Marconi, D. Martinet, F. Masclaux, M. Metrailler, P. Meyer, V. McLin, B. Micheli, S. Moll, A. Murphy, M. Namdar, T. Nouspikel, C. Ormières, P. Parvex, F. Picard, L. Quteineh, T. Rio Frio, M. Rebollo Polo, N. Rock, A.-L. Rougemont, L. Rubbia-Brandt, V. Schwitzgebel, M. Seeck, S. de Seigneux, P. Senn, S. Sizonenko, S. Suchet, M. Theate, C. Tran, R. van Heurck, MI Vargas, S. Vulliémoz, A. Wilhelm-Bals, G. van Winckel, O. Zgheib, M. Abramowicz. Utilité clinique des genome boards pour les maladies génétiques complexes. Rev med Suisse 2023 (in press)
  6. F. Picard. Ecstatic or mystical experience through epilepsy. J Cogn Neurosci 2023; 35: 1372-1381. Doi: 10.1162/jocn_a_02031
  7. P. De Stefano, H. Quintard, N. Siegenthaler, M. Seeck, F. Picard. Rapid recovery of EEG changes in severe hepatic encephalopathy following liver transplantation. Practical Neurology 2023; 23 (3): 253-254. Doi: 10.1136/pn-2022-003659
  8. P. De Stefano, D. Flügel, P. Agazzi, F. Picard, M. Seeck. Crise inaugurale: l’importance d’un diagnostic et traitement précoces. Swiss Medical Forum (in press)
  9. C. Timmermann, P.R. Bauer , O. Gosseries, A. Vanhaudenhuyse, F. Vollenweider, S. Laureys, T. Singer, the MLE-ENCECON research group (T. Barnhofer, O. Blanke, Q. Deeley, M.-E. Faymonville, D. Hangartner, I. Kotsou, M. Lifshitz, R. Lorenz, G. Pagnoni, C. Petitmengin, F. Picard, P. Rainville, A. Roepstorff, C. Sombrun, K. Suzuki, F. Taulelle, D.B. Terhune, M. van Vugt, H. Yeshe), E. Antonova, A. Lutz. A neurophenomenological approach to non-ordinary states of consciousness: hypnosis, meditation and psychedelics. Trends Cogn Sci 2023; 27 (2):139-159. Doi: 10.1016/j.tics.2022.11.006
  10. U. Nencha, L. Spinelli, S. Vulliemoz, M. Seeck, F. Picard. Insular stimulation produces mental clarity and bliss. Ann Neurol 2022; 91 (2):289-292. Doi: 10.1002/ana.26282
  11. F. Picard, P. Bossaerts, F. Bartolomei. Epilepsy and ecstatic experiences: the role of the insula. Brain Sci 2021. 11(11):1384. Doi: 10.3390/brainsci11111384.
  12. A. Bacq, D. Roussel, T. Bonduelle, S. Zagaglia, M. Maletic, T. Ribierre, H. Adle-Biassette, C. Marchal, M. Jennesson, I. An, Genomics England Research Consortium, F. Picard, V. Navarro, S.M. Sisodiya, S. Baulac. Cardiac investigations in sudden unexpected death  in DEPDC5-related epilepsy. Ann Neurol 2021. Doi: 10.1002/ana.26256.  
  13. C.M. Bonardi, H.O. Heyne, M. Fiannacca, M.P. Fitzgerald, E. Gardella, B. Gunning, K. Olofsson, G. Lesca, N. Verbeek, H. Stamberger, P. Striano, F. Zara, M.M. Mancardi, C. Nava, S. Syrbe, S. Buono, L.M. Dibbens, S. Baulac, A. Coppola, S. Weckhuysen, A.-S. Schoonjans, B. Ceulemans, C. Sarret, T. Baumgartner, H. Muhle, V. des Portes, J. Toulouse, M.-C. Nougues, M. Rossi, G. Demarquay, D. Ville, E. Hirsch, H. Maurey, M. Willems, J. de Bellescize, C. Desmettre Altuzarra, N. Villeneuve, F. Bartolomei, F. Picard, F. Hornemann, D.A. Koolen, H.Y. Kroes, W.-H. Tan, C. Reale, C.D. Fenger, D.R. Bearden, R.S. Møller, G. Rubboli. KCNT1-related epilepsies and epileptic encephalopathies : phenotypic and mutational spectrum. Brain 2021; 144 (12):3635-3650. Doi: 10.1093/brain/awab219
  14. N. Mella, F. Grouiller, M. Mouthon, F. Picard. Neural concomitants of remote memory in a comedian with exceptional verbal memory. J Cogn Enhanc 2021; 5: 351-358.
  15. N. Vernaz, T. Agoritsas, A. Calmy, A. Gayet-Ageron, G. Gold, A. Perrier, F. Picard, V. Prendki, JL. Reny, C. Samer, J. Stirnemann, P. Vetter, MC. Zanella, D. Zekry, S. Baggio. Early experimental Covid-19 therapies: associations with length of hospital stay, mortality, and related costs. Swiss Med Wkly 2020. 150:w20446. Doi: 10.4414/smw.2020.20446. 
  16. R. Markhus,  O. Henning, H. Krestel, E. Molteberg, E. Hirsch, S. Rheims, R. Surges, H. Hecimovic, K. Malmgren, S. Rüegg, A. Gil-Nagel, R. Roivainen, A.O. Tarta, F. Picard, B.J. Steinhoff, P. Marusic, V. Kimiskidis, I. Mindruta, R. Mameniskiené, A. Schulze-Bonhage, F. Rosenow, A. Kelemen, D. Fabó, M. Walker, M. Seeck, G. Krämer, C. Jagella, B. Mostacci, A. Ujvár, M. Lossius. EEG in fitness to drive evaluations in people with epilepsy – Considerable variations across Europe. Seizure 2020 ; 79: 56-60. Doi : 10.1016/j.seizure.2020.04.013
  17. S. Pichon, V. Garibotto, M. Wissmeyer, Y. Seimbille, L. Antico, O. Ratib, P. Vuilleumier, S. Haller, F. Picard. Higher availability of α4β2 nicotinic receptors (nAChRs) in dorsal ACC is linked to more efficient interference control. NeuroImage 2020; 214:116729. Doi: 10.1016/j.neuroimage.2020.116729
  18. K. Lossius, A. de Saint Martin, S. Myren-Svelstad, M. Bjornvold, G. Minken, C. Seegmuller, M.P. Valenti Hirsch, J. Chelly, O. Steinlein, F. Picard, E. Brodtkorb. Remarkable effect of transdermal nicotine in children with CHRNA4-related autosomal dominant sleep-related hypermotor epilepsy. Epilepsy Behav 2020; 105: 106944. Doi: 10.1016/j.yebeh.2020.106944
  19. D. Reser, F. Picard. Editorial Summary: Structure and Function of the Insula-Claustrum Region Front Neuroanat 2020; 14:14. doi 10.3389/fnana.2020.00014
  20. V. Garibotto, M. Wissmeyer, O. Ratib, F. Picard. Nicotinic acetylcholine receptor density in the “higher-order” thalamus projecting to the prefrontal cortex in humans: a PET study. Mol Imaging Biol 2020; 22(2): 417-424. Doi: 10.1007/s11307-019-01377-8
  21. F. Bartolomei, S. Lagarde, D Scavarda, R Carron, CG Bénar, F. Picard. The role of the dorsal anterior insula in ecstatic sensation revealed by direct electrical brain stimulation. Brain Stim 2019; 12(5):1121-1126. Doi: 10.1016/j.brs.2019.06.005
  22. V. Garibotto, T. Corpataux, E. Dupuis-Lozeron, S. Haller, T. Fontolliet, F. Picard. Higher nicotinic receptor availability in the cingulo-insular network is associated with lower cardiac parasympathetic tone. J Comp Neurol 2019; 527(18): 3014-3022.
  23. J. Tomás, F. Pittau, A. Hammers, S. Bouvard, F. Picard, M.I. Vargas, F. Sales, M. Seeck, V. Garibotto. The predictive value of hypometabolism in focal epilepsy: a prospective study in surgical candidates. Eur J Nucl Med Mol Imaging 2019; 46(9): 1806-1816. Doi: 10.1007/s00259-019-04356-x 
  24. G. Rubboli, G. Plazzi, F. Picard, L. Nobili, E. Hirsch, J. Chelly, R.A. Prayson, J. Boutonnat, M. Bramerio, P. Kahane, L.M. Dibbens, E. Gardella, S. Baulac, R.S. Møller. Mild malformations of cortical development in sleep-related hypermotor epilepsy due to KCNT1 mutations. Ann Clin Transl Neurol 2019; 6(2): 386-391. Doi: 10.1002/acn3.708
  25. N. Mella, A. Bourgeois, F. Perren, A. Viaccoz, M. Kliegel, F. Picard. Does the insula contribute to emotion-related distortion of time? A neuropsychological approach. Hum Brain Mapp 2019; 40(5): 1470-1479. Doi: 10.1002/hbm.24460
  26. V. Garibotto, M. Wissmeyer, Z. Giavri, R. Goldstein, Y. Seimbille, M. Seeck, O. Ratib, S. Haller, F. Picard. Nicotinic receptor abnormalities as biomarker in idiopathic generalized epilepsy. Eur J Nucl Med Mol Imaging 2019; 46 (2): 385-395. Doi: 10.1007/s00259-018-4175-0
  27. S. Baldassari, F. Picard, et al, S. Baulac. The landscape of epilepsy-related GATOR1 variants. Genet Med 2019; 21 (2): 398-408. Doi: 10.1038/s41436-018-0060-2
  28. C. O’Reilly, F. Chapotot, F. Pittau, N. Mella, F. Picard. Nicotine increases sleep spindle activity. J Sleep Res 2018. Doi: 10.1111/jsr.12800
  29. I. Constantinescu, C. Korff, S. Vulliemoz, F. Picard, M. Seeck. Drug level monitoring on admission for presurgical epilepsy evaluation. Eur Neurol 2017; 78(1-2): 105-110. doi: 10.1159/000479003
  30. P. Ryvlin, F. Picard. Invasive investigation of insular cortex epilepsy. J Clin Neurophysiol 2017; 34(4):328-332. Doi: 10.1097/WNP.0000000000000395
  31. M. Gschwind, F. Picard. Ecstatic epileptic seizures: a glimpse into the multiple roles of the insula. Front Behav Neurosci 2016; 10:21. doi: 10.3389/fnbeh.2016.00021
  32. L. Fisch, A.M. Lascano, N. Vernaz Hegi, F. Girardin, V. Kapina, L. Heydrich, O. Rutschmann, M.I. Vargas, F. Picard, S. Vulliemoz, A.C. Heritier-Barras, M. Seeck. Early specialized care after a first unprovoked epileptic seizure. J Neurol 2016, 263(12):2386-2394. Doi: 10.1007/s00415-016-8272-3
  33. O. Torriani, F. Vuilleumier, T. Perneger, P.-A. Despland, M. Maeder, A.-C. Héritier-Barras, S. Vulliemoz, M. Seeck, A.O. Rossetti, F. Picard. Epilepsy and tobacco consumption, a prevalence epidemiological survey. J Neurol 2016, 263(10), 2057-2064. Doi: 10.1007/s00415-016-8228-7 
  34. P. Makrythanasis, C. Behr, S. Baulac, E. Hirsch, F. Picard. Choking fits during sleep related to epilepsy. Am J Med 2016; 129(8): e137-8. doi: 10.1016/j.amjmed.2016.04.010. (PRD 08-II-1)
  35. S. Weckhuysen, E. Marsan, V. Lambrecq , C. Marchal, M. Morin-Brureau, I. An-Gourfinkel, M. Baulac, M. Fohlen, C. Kallay Zetch, M. Seeck, P. Legrange, B. Dermaut, A. Meurs, F. Chassoux, E. Leguern, F. Picard, S. Baulac. Involvement of GATOR complex genes in familial focal epilepsies and focal cortical dysplasia. Epilepsia 2016; 57(6):994-1003. doi: 10.1111/epi.13391
  36. A. Lascano, C. Korff, F. Picard. Epilepsies due to channelopathies: a parallel between genetic and immune aspects. Molecular Syndromology 2016; 7: 197-209. doi: 447707
  37. N. Nicastro, F. Picard. Reply to Kamtchum-Tatuene and Fogang. Epilepsy Behav 2016; 58: 139-140. doi: 10.1016/j.yebeh.2016.02.028
  38. P. Tinuper, F. Bisulli, J.H. Cross, D. Hesdorffer, P. Kahane, L. Nobili, F. Provini, I.E. Scheffer, L. Tassi, L. Vignatelli, C. Bassetti, F. Cirignotta, C.P. Derry, A. Gambardella, R. Guerrini, P. Halasz, L. Licchetta, M.W. Mahowald, R. Manni, C. Marini, B. Mostacci, I. Naldi, L. Parrino, F. Picard, M. Pugliatti, P. Ryvlin, F. Vigevano, M. Zucconi,   S.F. Berkovic, R. Ottman. Definition and diagnostic criteria of sleep-related hypermotor epilepsy (SHE). Neurology 2016; 86: 1-9. doi: 10.1212/WNL.0000000000002666
  39. N. Nicastro, F. Picard. Joan of Arc: Sanctity, Witchcraft or Epilepsy? Epilepsy Behav 2016; 57: 247-250. 
  40. M. Boillot, M. Morin-Brureau, F. Picard, S. Weckhuysen, V. Lambrecq, C. Minetti, P. Striano, F. Zara, M. Iacomino, S. Ishida, I. An-Gourfinkel, M. Daniau, M. Baulac, O. Dulac, E. Leguern, R. Nabbout, S. Baulac. Novel GABRG2 mutations cause familial febrile seizures. Neurol Genet 2015; 1: e35. doi: 10.1212/NXG.0000000000000035
  41. A.D. Korczyn, S.C. Schachter, J. Amlerova, M. Bialer, W. van Emde Boas, M. Brázdil, E. Brodtkorb, J. Engel, J. Gotman, V. Komárek, I.E. Leppik, P. Marusic, S. Meletti, B. Metternich, C. Moulin, N. Muhlert, M. Mula, K.O. Nakken, F. Picard, A. Schulze-Bonhage, W. Theodore, P. Wolf, A. Zeman, I. Rektor. Third International Congress on Epilepsy, Brain and Mind: Part 1. Epilepsy Behav 2015; 50: 116-137.
  42. S. Baulac, S. Ishida, E. Marsan, C. Miquel, A. Biraben, D.K. Nguyen, D. Nordli, P. Cossette, S. Nguyen, V. Lambrecq, M. Vlaicu, M. Daniau, F. Bielle, E. Andermann, F. Andermann, E. Leguern, F. Chassoux, F. Picard. Familial focal epilepsy with focal cortical dysplasia due to DEPDC5 mutations. Ann Neurol 2015; 77: 675-683. doi: 10.1002/ana.24368
  43. M.Z. Koubeissi, F. Bartolomei, A. Beltagy, F. Picard. Electrical stimulation of a small brain area reversibly disrupts consciousness. Epilepsy Behav 2014; 37: 32-35.
  44. F. Picard, P. Makrythanasis, V. Navarro, S. Ishida, J. de Bellescize, D. Ville, M. Vasselon Raina, G. Lesca, I. An-Gourfinkel, M. Baulac, E. Mundwiller, P. Couarch, S.E. Antonarakis, E. Leguern, O. Steinlein, S. Baulac. DEPDC5 mutations in families presenting as autosomal dominant nocturnal frontal lobe epilepsy. Neurology 2014; 82: 2101-2106. doi: 10.1212/WNL.0000000000000488
  45. F. Picard, F. Kurth. Ictal alterations of consciousness during ecstatic seizures. Epilepsy Behav 2014; 30: 58-61. PMID: 24436968.
  46. N. Nicastro, F. Picard, F. Assal. Transient global amnesia-mimics: transient epileptic amnesia. Epilepsy Behav Case Rep 2014; 2: 100-101.
  47. F. Picard, K. Friston. Predictions, perception and a sense of self. Neurology 2014; 83: 1112-1118. doi: 10.1212/WNL.0000000000000798
  48. F. Picard, D. Scavarda, F. Bartolomei. Induction of a sense of bliss by electrical stimulation of the anterior insula. Cortex 2013; 49: 2935-2937. 
  49. F. Picard, S. Sadaghiani, C. Leroy, D.S. Courvoisier, R. Maroy, M. Bottlaender. High density of nicotinic receptors in the cingulo-insular network. NeuroImage 2013; 79: 42-51.
  50. S. Ishida, F. Picard, G. Rudolf, E. Noé, G. Achaz, P. Thomas, P. Genton, E. Mundwiller, M. Wolff, C. Marescaux, R. Miles, M. Baulac, E. Hirsch, E. Leguern, S. Baulac. Mutations of DEPDC5 cause autosomal dominant focal epilepsies. Nat Genet 2013; 45: 552-555.
  51. F. Picard. State of belief, subjective certainty and bliss as a product of cortical dysfunction. Cortex 2013; 49: 2494-2500.
  52. C.M. Korff, S. Vulliemoz, F. Picard, J. Fluss. Ohtahara syndrome or early-onset West syndrome? A case with overlapping features and favorable response to vigabatrin. Eur J Paediatr Neurol 2012; 16: 753-757.
  53. A. Méneret,  D. Grabli, C. Depienne, C. Gaudebout, F. Picard, A. Dürr, I. Lagroua, D. Bouteiller, C. Mignot, D. Doummar, M. Anheim, C. Tranchant, P. Burbaud, C.P. Jedynak, D. Gras, D. Steschenko, D. Devos, T. Billette de Villemeur, M. Vidailhet, A. Brice, E. Roze. PRRT2 mutations: a major cause of paroxysmal kinesigenic dyskinesia in the European population. Neurology 2012; 79: 170-174.
  54. F. Picard. Vincent van Gogh’s epilepsy. Epilepsy Behav 2011; 22: 414-415.
  55. P. Mégevand, M.I. Vargas, H. Yilmaz, F. Picard. A distinctive watershed area in the vertebrobasilar territory. Neurology 2011; 77: 1016-1018.
  56. I. Bouchardy, O. Steinlein, R. Combi, L. Ferini-Strambi, A. Gambardella, G. Rudolf, M.A. Morris, F. Picard. Mutations of the orexin system, a regulator of sleep arousal, are not a common cause of ADNFLE. Neurology 2011; 76: 1272-1273. (PRD 08-II-1)
  57. C. Marelli, J. van de Leemput, J.O. Johnson, F. Tison, C. Thauvin-Robinet, F. Picard, C. Tranchant, D.G. Hernandez, B. Huttin, J. Boulliat, I. Sangla, C. Marescaux , S. Brique, H. Dollfus, S. Arepalli, I. Benatru, E. Ollagnon, S. Forlani, J. Hardy, G. Stevanin, A. Dürr, A. Singleton, A. Brice. SCA15 due to large ITPR1 deletions in a cohort of 333 Caucasian families with dominant ataxia. Arch Neurol 2011: 68: 637-643.
  58. F. Villéga, F. Picard, C. Espil-Taris, M. Husson, V. Michel, J.-M. Pedespan. Benign nocturnal alternating hemiplegia of childhood: two cases with positive evolution. Brain Dev 2011; 33: 525-529. 
  59. V. Kapina, F. Sedel, A. Truffert, J. Horvath, R.J.A. Wanders, H.R. Waterham, F. Picard. Relapsing rhabdomyolysis due to peroxisomal a-methylacyl-CoA racemase deficiency. Neurology 2010; 75: 1300-1302.
  60. F. Picard. Epileptic feeling of multiple presences in the frontal space. Cortex 2010; 46: 1037-1042.
  61. V. Kapina, M.-I. Vargas, S. Vulliemoz, T. Landis, F. Picard, P.H. Lalive. VGKC antibody-associated encephalitis, microbleeds and progressive brain atrophy. J Neurol 2010; 257: 466-468.
  62. F. Picard, B.N. Landis. Pine nut-induced dysgeusia: an emerging problem! Am J Med 2010; 123 (11): e3.
  63. F. Picard, A.D. Craig. Ecstatic epileptic seizures: a potential window on the neural basis for human self-awareness. Epilepsy Behav 2009; 16: 539-546. 
  64. F. Loup, F. Picard, Y. Yonekawa, H.-G. Wieser, J.-M. Fritschy. Selective changes in GABAA receptor subtypes in white matter neurons of patients with focal epilepsy. Brain 2009; 132: 2449-2463. 
  65. F. Clot, D. Grabli, C. Cazeneuve, E. Roze, P. Castelnau, B. Chabrol, P. Landrieu, K. Nguyen, G. Ponsot, M. Abada, D. Doummar, P. Damier, R. Gil, S. Thobois, A.J.Ward, A. Toutain, F. Picard, A. Camuzat, E. Fedirko, C. Sân, D. Bouteiller, E. LeGuern, A. Durr, M. Vidailhet, A. Brice, and the French Dystonia Network. Exhaustive analysis of BH4 and dopamine biosynthesis genes in patients with dopa-responsive dystonia. Brain 2009; 132: 1753-1763.
  66. F. Sperli, D. Rentsch, P.A. Despland, G. Foletti, P. Jallon, F. Picard, T. Landis, M. Seeck. Psychiatric comorbidity in patients evaluated for chronic epilepsy: a differential role of the right hemisphere? Eur Neurol 2009; 61: 350-357.
  67. F. Picard, A.J. Pegna, V. Arntsberg, N. Lucas, I. Kaczmarek, O. Todica, C. Chiriaco, M. Seeck, E. Brodtkorb. Neuropsychological disturbances in frontal lobe epilepsy due to mutated nicotinic receptors. Epilepsy & Behavior 2009; 14: 354-359.
  68. E. Chabrol, I. Gourfinkel-An, I.E. Scheffer, F. Picard, P. Couarch, S.F. Berkovic, J.M. McMahon, N. Bajaj, L. Mota-Vieira, R. Mota, O. Trouillard, C. Depienne, M. Baulac, E. LeGuern, S. Baulac. Absence of mutations in the LGI1 receptor ADAM22 gene in autosomal dominant lateral temporal epilepsy. Epilepsy Res 2007; 76: 41-48. 
  69. F. Picard, P. Mégevand, L. Minotti, P. Kahane, P. Ryvlin, M. Seeck, C. Michel, G. Lantz. Intracerebral recordings of nocturnal hyperkinetic seizures: demonstration of a longer duration of the pre-seizure sleep spindle. Clin Neurophysiol 2007; 118: 928-939. 
  70. P. Mégevand, C. Chizzolini, M. Chofflon, P. Roux-Lombard, P.H. Lalive, F. Picard. Cerebrospinal fluid anti-SSA autoantibodies as a marker of central nervous system involvement in Sjögren’s syndrome. Eur Neurol 2007; 57: 166-171.
  71. F. Loup, F. Picard, V. André, P. Kehrli, Y. Yonekawa, HG. Wieser, JM. Fritschy. Altered expression of a3-containing GABAA receptors in the neocortex of patients with focal epilepsy. Brain 2006; 129: 3277-3289.
  72. E. Brodtkorb, F. Picard. Tobacco habits modulate autosomal dominant nocturnal frontal lobe epilepsy. Epilepsy & Behavior 2006; 9: 515-520.
  73. S. Vulliemoz, F. Lurati-Ruiz, F-X. Borruat, J. Delavelle, I.J. Koralnik, J. Bogousslavsky, F. Picard, T. Landis, R.A. Du Pasquier. Favorable outcome of progressive multifocal leukoencephalopathy in two patients with dermatomyositis. J Neurol Neurosurg Psychiatry 2006; 77: 1079-1082.
  74. F. Picard, D. Bruel, D. Servent, W. Saba, C. Fruchart-Gaillard, M.-A. Schöllhorn-Peyronneau, D. Roumenov, E. Brodtkorb, S. Zuberi, A. Gambardella, B. Steinborn, A. Hufnagel, H. Valette, M. Bottlaender. Alteration of the in vivo nicotinic receptor density in ADNFLE patients, a PET study. Brain 2006; 129: 2047-2060. 
  75. P. Ryvlin, L. Minotti, G. Demarquay, E. Hirsch, A. Arzimanoglou, D. Hoffman, M. Guénot, F. Picard, S. Rheims, P. Kahane. Nocturnal hypermotor seizures, suggesting frontal lobe epilepsy, can originate in the insula. Epilepsia 2006; 47: 755-765.
  76. F. Picard, S. Guidoux, T. Martin, P. Aubourg, J-L Pasquali. T-cell receptor Vb gene usage in CSF lymphocytes in X-linked adrenoleukodystrophy. J Mol Recognit 2005; 18: 254-261. 
  77. D. Le Fort, A.B. Safran, F. Picard, I. Bouchardy, M.A. Morris. Elicited repetitive daily blindness: a new familial disorder related to migraine and epilepsy. Neurology 2004; 63: 348-350.
  78. P.L. Di Patre, V. Castillo, J. Delavelle, S. Vuillemoz, F. Picard, T. Landis. “Tumor-mimicking” multiple sclerosis. Clin Neuropathol 2003; 22: 235-239.
  79. T. Sander, C. Windemuth, H. Schulz , K. Saar, E. Gennaro, C. Riggio, A. Bianchi, F. Zara, G. Rudolf, F. Picard, C. Bulteau, A. Kaminska, C. Cieuta, JF. Prud'homme, O. Dulac, L. Bate, R. Robinson, R.M. Gardiner, A. Covanis, G.J. De Haan, G.A. Janssen, M.G. Van Erp, E.H. Boezeman, D. Lindhout, A. Heils, P. Nurnberg, D. Janz. Exploration of a putative susceptibility locus for idiopathic generalized epilepsy on chromosome 8p12. Epilepsia 2003; 44:32-39.
  80. D. Bertrand, F. Picard, S. Le Hellard, S. Weiland, I. Favre, H. Phillips, S. Bertrand, S.F. Berkovic, A. Malafosse, J. Mulley. How mutations in the nAChRs can cause ADNFLE epilepsy. Epilepsia 2002; 43 (Suppl5): 112-122.
  81. D. Cruzado, V. Masserey-Spicher , L. Roux , J. Delavelle , F. Picard , CA. Haenggeli . Early onset and rapidly progressive subacute sclerosing panencephalitis after congenital measles infection. Eur J Pediatr 2002; 161: 438-441.
  82. V. Chaves Vischer, M. Maeder-Ingvar, F. Picard, C. Mayor Dubois, V. Davidoff, T. Déonna, C.A. Haenggeli, E. Roulet Perez. Epileptic falls and gait disturbance in two young children with a sharp wave focus at the vertex: a variant of benign partial epilepsy of childhood? Eur J Paediatr Neurol 2002; 6: 169-178.
  83. V. Chaves-Vischer, F. Picard, E. Andermann, B. Dalla Bernardina, F. Andermann. Benign nocturnal alternating hemiplegia of childhood: six patients and long-term follow-up. Neurology 2001; 57: 1491-1493. 
  84. B. Moulard, F. Picard, S. le Hellard, C. Agulhon, S. Weiland, I. Favre, S. Bertrand, A. Malafosse, D. Bertrand. Ion channel variation causes epilepsies. Brain Res Rev 2001; 36: 275-284.
  85. T. Moore, S. Hecquet, A. McLellan, D. Ville, D. Grid, F. Picard, B. Moulard, P. Asherson, A. J. Makoff, D. McCormick, L. Nashef, P. Froguel, A. Arzimanoglou, E. LeGuern, B. Bailleul. Polymorphism analysis of JRK/JH8, the human homologue of mouse jerky, and description of a rare mutation in a case of CAE evolving to JME. Epilepsy Res 2001; 46: 157-167.
  86. M. Seeck, O. Blanke, P. Jallon, F. Picard, S. Zaim. Symptomatic postictal cardiac asystole in a young patient with partial seizures. Europace 2001; 3: 247-252.
  87. A. de Saint-Martin, F. Picard, E. Hirsch, M. Fischbach. Ionic channels and epilepsy. Arch Pediatr 2001; 8 Suppl 2 : 296-297.
  88. S. Baulac, F. Picard, A. Herman, J. Feingold, J.-F. Prud’homme, E. Hirsch, M. Baulac, A. Brice, E. LeGuern. Evidence for digenic inheritance in a family with both febrile convulsions and temporal lobe epilepsy implicating chromosomes 18qter and 1q25-q31. Ann Neurol 2001; 49: 786-792.
  89. P. Jallon and F. Picard. Bodyweight gain and anticonvulsants: a comparative review. Drug Safety 2001; 24: 969-978.
  90. P. Jallon, L. Fankhauser, R. Du Pasquier, A. Coeytaux, F. Picard, S. Hefft, F. Assal. Severe but reversible encephalopathy associated with cefepime. Neurophysiol Clin 2000; 30: 383-386.
  91. B. Maton, F. Picard, A. Njamshi, S. Roth, D. Slosman, R. Sztajzel, P. Jallon, T. Landis. Encephalopathy with epileptic spasms resolved with corticoids in a 69 year-old patient. Epileptic Disorders 2000; 2: 123-125.    
  92. F. Picard, S. Baulac, P. Kahane, E. Hirsch, R. Sebastianelli, P. Thomas, F. Vigevano, P. Genton, R. Guerrini, C.A. Gericke, I. An, G. Rudolf, A. Herman, A. Brice, C. Marescaux, E. LeGuern. Dominant partial epilepsies: a clinical, electrophysiological and genetic study of 19 European families. Brain 2000; 123: 1247-1262. 
  93. T. Sander, H. Schulz, K. Saar, E. Gennaro, M. C. Riggio, A. Bianchi, F. Zara, D. Luna, C. Bulteau, A. Kaminska, D. Ville, C. Cieuta, F. Picard, J.-F. Prud'Homme, L. Bate, A. Sundquist, R.M. Gardiner, G.A. Janssen, G.-J. de Haan, D.G.A. Kasteleijn-Nolst-Trenité, A. Bader, D. Lindhout, O. Riess, T.F. Wienker, D. Janz, A. Reis. Genome search for susceptibility loci of common idiopathic generalised epilepsies. Hum Mol Genet 2000; 9: 1465-1472.
  94. C.A. Gericke, F. Picard, A. de Saint-Martin, S. Strumia, C. Marescaux, E. Hirsch. Efficacy of lamotrigine in idiopathic generalized epilepsy syndromes: a video-EEG-controlled, open study. Epileptic disorders 1999; 1: 159-165.
  95. S. Baulac, I. Gourfinkel-An, F. Picard, M. Rosenberg-Bourgin, J-F. Prud’homme, M. Baulac, A. Brice, E. LeGuern. A second locus for familial generalized epilepsy with febrile seizures plus (GEFS+) maps to chromosome 2q21-q33. Am J Hum Genet 1999; 65: 1078-1085.
  96. F. Picard, S. Bertrand, O.K. Steinlein, D. Bertrand. Mutated nicotinic receptors responsible for autosomal dominant nocturnal frontal lobe epilepsy are highly sensitive to carbamazepine. Epilepsia 1999; 40: 1198-1209.
  97. F. Picard, P. Chauvel. Autosomal dominant nocturnal frontal lobe epilepsy: the syndrome. Rev Neurol 1999; 155: 445-449.
  98. Pegna, F. Picard, M.-D. Martory, P. Vuillemier, M. Seeck, P. Jallon, T. Landis. Semantically-triggered reading epilepsy: an experimental case study. Cortex 1999; 35: 101-111.
  99. F. Picard, J. Tassin, M. Vidailhet, C. Marescaux, Y. Agid, A. Brice. Autosomal dominant paroxysmal kinesigenic choreoathetosis: a clinical and genetic study of 2 families. J Neurol Neurosurg Psychiatry 1998; 65: 955-956.
  100. P. Thomas, F. Picard, E. Hirsch, M. Chatel, C. Marescaux. Autosomal dominant nocturnal frontal lobe epilepsy. Rev Neurol 1998; 154: 228-235.
  101. J.P. Rubio, A. Danek, C. Stone, R. Chalmers, N. Wood, C. Verellen, X. Ferrer, A. Malandrini, G.M. Fabrizi, M. Manfredi, J. Vance, M. Pericak-Vance, R. Brown, G. Rudolf, F. Picard, E. Alonso, M. Brin, A.H. Németh, M. Farrall, A.P. Monaco. Choreo-acanthocytosis: genetic linkage to chromosome 9q21. Am J Hum Genet 1997; 61: 899-908.
  102. F. Picard, C. A. Gericke, M. Frey, M. Collard. Varicella with acute motor axonal neuropathy. Eur Neurol 1997; 38: 68-71.
  103. A.de Saint Martin, N. Badinand, F. Picard, M. Fischbach, M.J. Challamel, C. Marescaux, E. Hirsch. Diurnal and nocturnal paroxysmal dyskinesia in young children: a new entity? Rev Neurol 1997; 153:262-267.
  104. F. Picard, A. de Saint-Martin, E. Salmon, E. Hirsch, C. Marescaux. Postencephalitic stereotyped involuntary movements responsive to L-Dopa. Mov Disord 1996; 11: 567-570.
  105. F. Picard, E. Hirsch, C. Marescaux. Familial partial epilepsies. Arch Pediatr 1996; 3: 925.
  106. F. Picard, E. Hirsch, E. Salmon, C. Marescaux, M. Collard. Parkinsonian syndrome and post-encephalitic stereotyped involuntary movements responsive to L-Dopa. Rev Neurol 1996; 152: 267-271.
  107. F. Picard, T. Martin, F. Legras, B. Lioure, J-L. Pasquali. Molecular analysis of T-cell receptor Vb chains of human T-cell chronic lymphocytic leukemia does not show intraclonal variability: implications for immunotherapy. Blood 1993; 82: 2152-2156.
  108. F. Sellal, F. Picard, V. Mutschler, C. Marescaux, M. Collard, J.F. Magnaval. Myelitis caused by toxocara canis (larva migrans). Rev Neurol 1992; 148: 53-55.
Dernière mise à jour : 24/01/2024