Supplementary data to our publications

On this page we are publishing data (for instance, large tables) that are not included in the printed version of the respective papers. These additional data are published as ".pdf" files and can be downloaded.


Impact of epidural analgesia on mortality and morbidity after surgery : systematic review and meta-analysis of randomized controlled trials.
Annals of Surgery 2014;259:1056-67
Pöpping DM, Elia N, Van Aken HK, Marret E, Schug SA, Kranke P, Wenk M, Tramèr MR.

Supplementary data :Table AFigure A ; Figure BFigure CFigure D ; Figure E ; Figure FTable B.


Combination of a reduced dose of an intrathecal local anesthetic with a small dose of an opioid. A meta-analysis of randomized trials. Pain 2013 ; 154:1383-1390.
Pöpping DM, Elia N, Wenk E, Tramèr MR  

IT-Opioids-SupplData-13-03-27-MT


Effect of intraoperative high inspired oxygen fraction on surgical site infection, postoperative nausea and vomiting, and pulmonary function : systematic review and meta-analysis of randomized controlled trials. Anesthesiology 2013 ; 119:303-16.
Hovaguimian F, Lysakowski C, Elia N, Tramèr MR 

Supplemental data (meta-analyses on PONV outcomes)


Effect of perioperative systemic  α2 agonists on postoperative morphine consumption and pain intensity : systematic review and meta-analysis of randomized controlled trials. Anesthesiology 2012 ; 116: 1312-1322.
Blaudszun G, Lysakowski C, Elia N, Tramèr MR.

Supplemental tables  


Ventilation strategies in obese patients undergoing surgery : a quantitative systematic review and meta-analysis. British Journal of Anaesthesia 2012;109:493-502.
Aldenkortt M, Lysakowski C, Elia N, Brochard L, Tramèr MR

Supplementary Data A
Supplementary Data B


Low-dose droperidol (≤1mg or 15 mg kg-1) for the prevention of postoperative nausea and vomiting in adults: quantitative systematic review of randomised controlled trials. European Journal of Anaesthesiology 2012 ; 29:286-294
Schaub I, Lysakowski C, Elia N, Tramèr MR


Opioids added to local anesthestics for single shot intrathecal anaesthesia in patients undergoing minor surgery. A Meta-analysis of randomized trials. Pain 2012 ; 153: 784-93
Pöpping D M, Elia N, Marret E, Wenk M, Tramèr MR


Supplemental data 1 ; Supplemental data 2 ; Supplemental data 3 ; Supplemental data 4 ; Supplemental data 5 ; Supplemental data 6 ; Supplemental data 7 ; Supplemental data 8 ; Supplemental data 9 ; Supplemental data 10 ; Supplemental data 11 ;  Supplemental data 12 .


Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks: a meta-analysis of randomized trials. Anesthesiology 2009 ; 111 :406-15
Pöpping D M, Elia N, Marret E, Wenk M, Tramèr MR  


Benefit and risk of intrathecal morphine without local anaesthetics in patients undergoing major surgery. Meta-analysis of randomised trials. Br J Anaesth 2009 ; 102:156-67
Meylan N, Elia N, Lysakowski C, Tramèr MR

Flow chart
Relation between year of publication and dose of intrathecal morphine
Extubation delay
Duration of hospital stay
 
Drug consumption:
Perioperative opioid requirements
24h morphine consumption
24h to 48h Morphine consumption
  
Pain measurments:
Pain intensity at rest at 2h
Pain intensity at rest at 4h
Pain intensity at rest at 12h
Pain intensity at rest at 24h
Pain intensity on movement at 12h
Pain intensity on movement at 24h
  
Adverse effects:
Nausea , Vomiting
Any pruritus , Pruritus needing treatment
Sedation
Respiratory depression
Pulmonary complications
Urinary retention  


Clonidine as an Adjuvant to Intrathecal Local Anesthetics for Surgery. Systematic Review of Randomized Trials. Regional Anesthesia and Pain Medicine 2008 ; 33(2):159-67
Elia N, Culebras X, Mazza C, Schiffer E, Tramèr M R

Included RCTs

The statistical model

Additional figures:
Time to regression to L2
Time to complete sensory block
Extent of cephalic spread of sensory block
Time to complete motor block
Intra-operative pain
Intra-operative hypotension
Intra-operative bradycardia

Additional figures (weight adjusted doses):
Figure 2
Figure 3
Figure 4
Time to regression to L2
Time to complete sensory block
Extent of cephalic spread of sensory block
Time to complete motor block
Intra-operative pain
Intra-operative hypotension
Intra-operative bradycardia


Impact of the Intubation Model on the Efficacy of Rocuronium during Rapid Sequence Intubation: Systematic Review of Randomised Trials. Acta Anaesthesiologica Scandinavica, 2007 ; 51: 848-857
Lysakowski C, Suppan L, Tassonyi E, Czarnetzki C, Tramèr MR

Analysed randomised controlled trials

Table 1: Randomized controlled trials of true rapid sequence intubation
Table 2: Randomized controlled trials of modified rapid sequence intubation   


Prevention of Succinylcholine-induced Fasciculation and Myalgia:
A Meta-analysis of Randomized Trials.
Anesthesiology, 2005 ; 103:877-84
Schreiber JU, Lysakowski C, Fuchs-Buder T, Tramèr MR

Analysed trials
A-L , M-Z
Fasciculation (individual meta-analyses)
Fasciculation
Myalgia (individual meta-analyses)
Myalgia


Does Multimodal Analgesia with Acetaminophen, Nonsteroidal Antiinflammatory Drugs or Selective Cyclooxygenase-2 Inhibitors and Patient-controlled Analgesia Morphine Offer advantages Over Morphine Alone? Meta-analyses of Randomized Trials. Anesthesiology, 2005 ; 103:1296-1304
Elia N, Lysakowski C, Tramèr MR

Analysed trials
Acetaminophen , COX-2 , NSAID
Table
Regimens tested

Detailed meta-analyses
Morphine sparing
Acetaminophen , COX-2 , NSAID
VAS pain intensity
Acetaminophen , NSAID
Morphine-related adverse effects
Acetaminophen , COX-2 , NSAID
Drug-related adverse effects
COX-2 , NSAID

Individual trial data
Morphine-related adverse-effects
Respiratory depression
Nausea
Vomiting
Nausea or vomiting
Urinary retention
Pruritus
Dizziness
Sedation
Bowel dysfunction
Drug-related adverse effects
Gastro-intestinal bleeding
Oliguria
Renal failure
Surgical bleeding    


Ketamine and postoperative pain: A quantitative systematic review of randomised trials. Pain 2005, 113:61-70 
Elia N, Tramèr MR

Analysed trials
Prophylactic iv. ketamine in adults
Ketamine added to an opioid in an iv. PCA device
Prophylactic epidural ketamine in adults
Therapeutic epidural ketamine in adults
Prolonged (>24 hours) iv. ketamine in adults
Iv. ketamine in sedated adults
Prophylactic intravenous ketamine in children
Prophylactic caudal ketamine in children
Other ketamine regimen

Figures
Flow chart
VAS of pain intensity
Cumulative morphine consumption
Opioid-related adverse effects
Time to first request of analgesic
Risk of hallucinations according to the weight adjusted ketamine dose


Is low-dose haloperidol a useful antiemetic? A meta-analysis of published and unpublished randomized trials.  Anesthesiology 2004 ; 101:1454-1463 
Büttner M, Walder B, Von Elm E, and Tramèr MR

Haloperidol as an antiemetic in chemo- and radiotherapy
Analysed trials
McNeil report: Haldol (haloperidol) injection injection for use as an antiemetic agent, McNeil Laboratories Inc. January, 1974  
Introduction (part I; p. 1-2 )
Phase II clinical evaluation (part II; p. 4-11 )
Phase III clinical evaluation (postoperative use) (part IIIa; p. 13-39 and 40-49 )
Phase III clinical evaluation (gastrointestinal use) (part IIIb; p. 50-76 and 77-91 )
Summary and conclusions, supporting information, appendix, references (part IV-VII; p. 93-99 )   


Efficacy and harm of pharmacological prevention of acute mountain sickness: quantitative systematic review.  BMJ 2000 ; 321:267-272
Dumont L, Mardirosoff C, Tramèr MR

Analysed trials